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Yes… and no! Actually during the image build, we must use dnf (because we’re not in a running system) and we can modify any directory as we would in a classic distro. It’s only once the image is deployed that we need to use rpm-ostree to manage packages.
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Patient leaflets on weight-loss injections state that gallstones are a "common" side effect, and in medical trials the injections also sometimes led to inflammation of the gallbladder. For example in Mounjaro, it has been reported this may affect up to 1 in 100 people.