For this story, WIRED reviewed dozens of NASA documents, including backup plans and contingencies for emergencies, and spoke to more than a dozen people, including three astronauts who’ve visited the ISS, and no one seemed that freaked out. One astronaut said the most worrisome scenario that actively crossed his mind in orbit was getting a toothache. The ISS has had some emergencies, including a first-ever medical evacuation in January, but generally things have been remarkably stable. In fact, one of the most impressive things about the ISS is that nothing very dramatic has ever happened to it. No experiment has gone too haywire. It hasn’t been hit by an asteroid.
Infigratinib靶向的FGFR3（成纤维细胞生长因子受体3）正是驱动ACH疾病发生的关键靶点，2月12日，BridgeBio公布Infigratinib在ACH中取得的首个具有统计学显著改善意义的3期顶线结果，公司计划下半年向FDA提交新药申请。
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